Barcelona thumped Man City 4-0 at the Camp Nou, but the Spanish champions will be without Gerard Pique, Andres Iniesta and Jordi Alba.
Claudi Bravo is suspended and both Bacary Sagna and Pablo Zabaleta missed the recent 4-0 win against West Brom, with Fernando filling in at right-back. However, Zabaleta is said to be back in training and could be ready to play at the Etihad.
Guardiola, though, is hardly going to tell his opponents, so here talkSPORT looks at how City could start.
Scroll through the gallery to see a possible line up for Barcelona's visit.